healthcareЗдравоохранение. HealthcareHealthcare1027-7218Republican Scientific and Practical Center for Medical Technologies, Informatization, Management and Health Economicshealthcare-106Research ArticleОБМЕН ОПЫТОМEXCHANGE OF EXPERIENCEВеб-приложение исследования эффективности доз излучения при изменении графика лучевого леченияWeb-application of model study of the effectiveness of radiation doses when the treatment schedule is modifiedБатянА. Н.BatyanA. N.

Батян Анатолий Николаевич — д. м. н., профессор, зав. кафедрой экологической медицины и радиобиологии.

Ул. Долгобродская, 23/1, 220070, Минск. Сл. тел.: +37S 17 379-90-96

ГончароваЕ. В.HancharovaК. V.

Минск

ГаидаА. В.HaidaA. V.

Брест

ДемешкоП. Д.DziameshkaP. D.

Минск

ЛемешевскииВ. О.LemiasheuskiV. O.

Минск

ОргишА. Н.OrgishA. N.ПеткевичМ. Н.PiatkevichM. N.

Минск

Международный государственный экологический институт им. А.Д. Сахарова БГУRussian FederationМеждународный государственный экологический институт им. А.Д. Сахарова БГУ; РНПЦ онкологии и медицинской радиологии им. Н.Н. АлександроваRussian FederationБрестский областной онкологический диспансерRussian FederationРНПЦ онкологии и медицинской радиологии им. Н.Н. АлександроваRussian Federation202423092025024552Copyright © Батян А.Н., Гончарова Е.В., Гаида А.В., Демешко П.Д., Лемешевскии В.О., Оргиш А.Н., Петкевич М.Н., 20252025Батян А.Н., Гончарова Е.В., Гаида А.В., Демешко П.Д., Лемешевскии В.О., Оргиш А.Н., Петкевич М.Н.Batyan A.N., Hancharova К.V., Haida A.V., Dziameshka P.D., Lemiasheuski V.O., Orgish A.N., Piatkevich M.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://healthcare.ejournal.by/jour/article/view/106

Целью исследования явилось изучение эффективности доз излучения при изменении графика лучевого лечения путем моделирования такого рода изменений в программном приложении «Линейно-квадратичная модель для медицинских физиков и радиационных онкологов», разработанном на основе теории линейно-квадратичной модели. В качестве материала модельного исследования рассмотрен случай изменения схемы лучевого лечения в режиме гипофракционирования РОД 2,66 Гр, СОД 42,56 Гр, α/β ЗГр при перерыве, увеличивающем продолжительность лечения с 22 до З1 дня. Проведен анализ снижения эффективности подводимых доз излучения при возникновении перерыва в лучевом лечении, если пропущенные фракции перенесены на конец курса ЛТ без внесения поправки в величину РОД.

Определена возможность компенсации потерь в эффективности подводимых доз излучения путем переноса пропущенных сеансов ЛТ на другие дни (субботу) и осуществления фракций в некоторые дни лечения 2 раза в день, а также учета пролиферации. Установлено, насколько нужно изменить РОД, чтобы добиться запланированного на начало лечения эффекта.

The aim of our study is to optimize calculations related to the evaluation of radiation doses when the radiation treatment schedule changes, by simulating such changes in the Web-application «Linear-quadratic model for medical physicists and radiation oncologists», developed on the basis of the theory of linear-quadratic model. As a model study material, we considered the case of changing the radiation treatment regimen in the mode of dose per fraction 2,66Gy to 42,56 Gy, α/β 3 Gy with an interruption that increases the number of days of treatment from 22 to З1. The evaluation was made of the decrease in the effectiveness of the delivered radiation doses when a break occurs in radiation treatment, if the missed fractions are transferred to the end of the RT course without adjusting the dose per fraction; the possibility of compensating for the loss in the effectiveness of the supplied radiation doses was determined by transferring the missed days to Saturday and carrying out fractions twice a day on some days of treatment, as well as taking into account proliferation; It is considered how much the dose needs to be changed per fraction to achieve the effect planned at the start of treatment.

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The authors declare that there are no conflicts of interest present.