healthcareЗдравоохранение. HealthcareHealthcare1027-7218Republican Scientific and Practical Center for Medical Technologies, Informatization, Management and Health Economicshealthcare-14Research ArticleЛЕКЦИИ И ОБЗОРЫLECTURES AND REVIEWSСовременные инструментальные параметрыи биохимические маркеры раннего сосудистого старенияModern instrumental parameters and biochemical markers of early vascular agingMoлocтоваА. М.MolostovaA. M.

Молостова Александра Михайловна — ассистент кафедры общей врачебной практики и поликлинической терапииул . Горького, 80, 230009, г. Гродно.

ЯкубоваЛ. В.YakubovaL. V.

Гродно

Гродненский государственный медицинский университетBelarus202422092025161019Copyright © Moлocтова А.М., Якубова Л.В., 20252025Moлocтова А.М., Якубова Л.В.Molostova A.M., Yakubova L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://healthcare.ejournal.by/jour/article/view/14

Одним из ключевых факторов риска сердечно-сосудистых заболеваний является возраст. При синдроме раннего сосудистого старения возраст-ассоциированная перестройка сосудистой стенки развивается быстрее, чем это происходит в популяции в среднем, и в итоге приводит к более раннему развитию сердечно-сосудистых заболеваний. Оценка артериальной жесткости по скорости распространения пульсовой волны на каротидно-феморальном участке является одним из основных методов диагностики раннего сосудистого старения. Для оценки артериальной жесткости также используют параметры центральной гемодинамики, такие как центральное систолическое и пульсовое артериальное давление, индекс аугментации, сердечно-лодыжечный сосудистый индекс. В статье приведены результаты исследований наиболее перспективных циркулирующих биомаркеров раннего сосудистого старения: высокочувствительный С-реактивный белок,  интерлейкины, ФНО-a, длина теломер и теломеразная активность, матричные металлопротеиназы, фактор дифференцировки роста-15, инсулиноподобный фактор роста-I, цистатин С, микро-РНК, которые уже показали высокую диагностическую значимость и требуют дальнейшего изучения. Приведены данные исследований по идентифицированному новому антивозрастному гену белка Klotho. Представлен большой арсенал современных инструментальных параметров и биохимических маркеров оценки раннего сосудистого старения, разработка и определение которых позволит улучшить диагностику как сердечно-сосудистых заболеваний, так и их осложнений.

One of the key risk factors for cardiovascular diseases is age. In early vascular aging syndrome age-associatedremodeling of the vascular wall develops faster than in the average population, ultimately leading to earlier onset ofcardiovascular diseases. Assessment of arterial stiffness by the velocity of pulse wave propagation in the carotid-femoralarea is one of the main methods for diagnosing early vascular aging syndrome. To assess arterial stiffness, parameters ofcentral hemodynamics are also used, such as central systolic and pulse blood pressure, augmentation index, measurementof the cardio-ankle vascular index. The review presents the results of studies of the most promising circulating biomarkersof early vascular aging syndrome: high-sensitivity С-reactive protein, interleukins, TNF-a, telomere length and telomeraseactivity, matrix metalloproteinases, growth differentiation factor-15, insulin-like growth factor-1, cystatin С, microRNA whichhave already shown high diagnostic significance and require further study. The research data on the identified new antiaging protein gene Klotho is presented. The article presents a large arsenal of modern instrumental parameters andbiochemical markers for assessing early vascular aging syndrome, the development and determination of which willimprove the diagnosis of both cardiovascular diseases and its complications.

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The authors declare that there are no conflicts of interest present.