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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">healthcare</journal-id><journal-title-group><journal-title xml:lang="ru">Здравоохранение. Healthcare</journal-title><trans-title-group xml:lang="en"><trans-title>Healthcare</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1027-7218</issn><publisher><publisher-name>Republican Scientific and Practical Center for Medical Technologies, Informatization, Management and Health Economics</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">healthcare-172</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАИ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASES FROM PRACTICE</subject></subj-group></article-categories><title-group><article-title>Туберкулезный менингит (клиническое наблюдение и оценка индекса Thwaites, консенсуса Lancet)</article-title><trans-title-group xml:lang="en"><trans-title>Tuberculous meningitis (clinical observation and evaluation Thwaites index, Lancet consensus)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лицкевич</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Litskevich</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лицкевич Лариса Владимировна - к. м. н., доцент кафедры фтизиопульмонологии</p><p>пр. Дзержинского, 83, 220083, г. Минск, БеларусьСл. тел. +375 17 258-88-23</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кривошеева</surname><given-names>Ж. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kryvasheyeva</surname><given-names>Zh. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск, Беларусь</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Астапов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Astapov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск, Беларусь</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Залуцкая</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Zalutskaya</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск, Беларусь</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джха</surname><given-names>Н. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Jha</surname><given-names>N. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нистант Кумар Джха</p><p>Минск, Беларусь</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мазхар</surname><given-names>С.</given-names></name><name name-style="western" xml:lang="en"><surname>Mazhar</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мазхар Сана</p><p>Минск, Беларусь</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Белорусский государственный медицинский университет</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>РНПЦ пульмонологии и фтизиатрии</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2025</year></pub-date><volume>0</volume><issue>12</issue><fpage>53</fpage><lpage>59</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лицкевич Л.В., Кривошеева Ж.И., Астапов А.А., Залуцкая О.М., Джха Н.К., Мазхар С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Лицкевич Л.В., Кривошеева Ж.И., Астапов А.А., Залуцкая О.М., Джха Н.К., Мазхар С.</copyright-holder><copyright-holder xml:lang="en">Litskevich L.V., Kryvasheyeva Z.I., Astapov A.A., Zalutskaya O.M., Jha N.K., Mazhar S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://healthcare.ejournal.by/jour/article/view/172">https://healthcare.ejournal.by/jour/article/view/172</self-uri><abstract><p>В статье рассмотрен случай заболевания 16-летнего подростка туберкулезным менингитом (ТМ), находящегося на лечении в Республиканском научно-практическом центре пульмонологии и фтизиатрии в течение 425 койко-дней. Целью статьи является обсуждение вероятности развития и тяжести туберкулезного менингита у одного и того же пациента с использованием данных клинического наблюдения и диагностических шкал (диагностический индекс Thwaites, 2004, консенсусная система Lancet, 2010). Результат применения диагностических индексов показывает высокую вероятность развития ТМ у пациента, что имеет значение для ранней диагностики заболевания. Клинические данные свидетельствуют о высокой степени тяжести случая ТМ. В исследовании подчеркивается необходимость использования и разработки более совершенных диагностических методов и шкал для пациентов с подозрением на ТМ.</p></abstract><trans-abstract xml:lang="en"><p>This article reviews the case of a 16-year-old adolescent patient with tuberculous meningitis (TM), who was admitted to the Republican Scientific and Practical Center for Pulmonology and Tuberculosis (RSPCPT) for 425 days. Thearticle aims to discuss the degree of likelihood and severity of NV in the same patient using diagnostic scales (Thwaites diagnostic index, 2002, Lancet Consensus System, 2010). The result on using of the diagnostic indexes shows high likelihood of TM in the patient. Clinical data also suggests the high severity of TM. The study highlights the need for use and development of more modern diagnostic methods and scales for the patients with suspected TM.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>туберкулезный менингит</kwd><kwd>диагностический индекс Thwaites</kwd><kwd>консенсусная система Lancet</kwd><kwd>множественная лекарственная устойчивость</kwd><kwd>спинномозговая жидкость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Tuberculous meningitis</kwd><kwd>Thwaites diagnostic index</kwd><kwd>Lancet consensus system</kwd><kwd>Multi drug resistant M. Tuberculosis</kwd><kwd>Cerebrospinal fluid</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Donovan J., Thwaites G. E., Huynh J. Tuberculous meningitis: where to from here? Curr. Opin. Infect. Dis. 2020. 33 (3): 259 66.</mixed-citation><mixed-citation xml:lang="en">Donovan J., Thwaites G. E., Huynh J. Tuberculous meningitis: where to from here? Curr. Opin. Infect. Dis. 2020. 33 (3): 259 66.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Pehlivanoglu F., Yasar K. K., Sengoz G. Tuberculous meningitis in adults: a review of 160 cases. Scientific World Journal. 2012; 2012: 169028.</mixed-citation><mixed-citation xml:lang="en">Pehlivanoglu F., Yasar K. K., Sengoz G. Tuberculous meningitis in adults: a review of 160 cases. Scientific World Journal. 2012; 2012: 169028.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Dr. Hari Kishan Boorugu, Dr. Varun Reddy, Dr. Arshad M Punjani (2020). Validation of Thwaites' Diagnostic Score in Adults with Tuberculous Meningitis. SAS Joumal of Medicine. 2020; 6: 166 -9.</mixed-citation><mixed-citation xml:lang="en">Dr. Hari Kishan Boorugu, Dr. Varun Reddy, Dr. Arshad M Punjani (2020). Validation of Thwaites' Diagnostic Score in Adults with Tuberculous Meningitis. SAS Joumal of Medicine. 2020; 6: 166 -9.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sulaiman T., Medi S., Erdem H. et al. The diagnostic utility of the «Thwaites' system» and «Lancet consensus scoring system» in tuberculous vs. non-tuberculous subacute and chronic meningitis: multicenter analysis of 395 adult patients. BMC Infect Dis. 2020; 20 (1): 788.</mixed-citation><mixed-citation xml:lang="en">Sulaiman T., Medi S., Erdem H. et al. The diagnostic utility of the «Thwaites' system» and «Lancet consensus scoring system» in tuberculous vs. non-tuberculous subacute and chronic meningitis: multicenter analysis of 395 adult patients. BMC Infect Dis. 2020; 20 (1): 788.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Thwaites G. E., Chau T. T. H., Stepniewska K. et al. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. The Lancet. 2002; 360: 1287-92.</mixed-citation><mixed-citation xml:lang="en">Thwaites G. E., Chau T. T. H., Stepniewska K. et al. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. The Lancet. 2002; 360: 1287-92.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Marais S., Thwaites G., Schoeman J. F. etal. Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect Dis. 2010; 10: 803 -12.</mixed-citation><mixed-citation xml:lang="en">Marais S., Thwaites G., Schoeman J. F. etal. Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect Dis. 2010; 10: 803 -12.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
