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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">healthcare</journal-id><journal-title-group><journal-title xml:lang="ru">Здравоохранение. Healthcare</journal-title><trans-title-group xml:lang="en"><trans-title>Healthcare</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1027-7218</issn><publisher><publisher-name>Republican Scientific and Practical Center for Medical Technologies, Informatization, Management and Health Economics</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">healthcare-193</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИИ И ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURES AND REVIEWS</subject></subj-group></article-categories><title-group><article-title>Редкие причины анафилаксии у детей и подростков, актуальность диагностики</article-title><trans-title-group xml:lang="en"><trans-title>Rare causes of anaphylaxis in children and adolescents and the relevance of diagnostics</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Василевский</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilevski</surname><given-names>I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рубан</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ruban</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Белорусский государственный медицинский университет</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>Институт биофизики и клеточной инженерии НАН Беларуси</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>7</issue><elocation-id>12—27</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Василевский И.В., Рубан А.П., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Василевский И.В., Рубан А.П.</copyright-holder><copyright-holder xml:lang="en">Vasilevski I., Ruban A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://healthcare.ejournal.by/jour/article/view/193">https://healthcare.ejournal.by/jour/article/view/193</self-uri><abstract><p>На основании современных данных литературы приводится комплексный анализ проблемы редких причин анафилаксии у детей и подростков. Подчеркивается, что это сложная задача в диагностическом плане, имеющая место в работе практикующего врача. Многие авторы указывают на недостаточное знание врачами клинической значимости редких причин детской анафилаксии и призывают к более глубокому освещению указанных вопросов. Рассмотрены вопросы анафилаксии, связанные с физической нагрузкой, с синдромом альфа-гал, оральной анафилаксией амбарных клещей, синдромом активации тучных клеток и др. Понимание роли указанных необычных триггеров имеет решающее значение для врачей, чтобы обеспечить точную диагностику и эффективное лечение детской анафилаксии, подчеркивается необходимость повышения клинической осведомленности в целях улучшения результатов лечения и повышения качества жизни детей и подростков, подверженных риску анафилактических реакций. Представленная информация имеет большое значение для практикующих врачей.</p></abstract><trans-abstract xml:lang="en"><p>Based on modern literature data, a comprehensive analysis of the problem of rare causes of anaphylaxis in children and adolescents is provided. It is emphasized that this is a complex task in terms of diagnostics, which takes place in the work of a practicing physician. Many authors point out that doctors have insufficient knowledge of the clinical significance of rare causes of childhood anaphylaxis and call for a more indepth coverage of these issues. The article provides a detailed review of anaphylaxis associated with exercise, alpha-gal syndrome, oral storage mite anaphylaxis, mast cell activation syndrome, etc. Understanding the role of these unusual triggers is critical for physicians to ensure accurate diagnosis and effective treatment of childhood anaphylaxis, emphasizing the need to increase clinical awareness to improve treatment outcomes and enhance the quality of life of children and adolescents at risk for anaphylactic reactions. The information presented is of great practical importance for practicing physicians.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>анафилаксия</kwd><kwd>дети</kwd><kwd>подростки</kwd><kwd>редкие причины анафилаксии</kwd><kwd>диагностика</kwd><kwd>профилактика</kwd><kwd>лечение</kwd><kwd>практикующие врачи</kwd></kwd-group><kwd-group xml:lang="en"><kwd>anaphylaxis</kwd><kwd>children</kwd><kwd>adolescents</kwd><kwd>rare causes of anaphylaxis</kwd><kwd>diagnosis</kwd><kwd>prevention</kwd><kwd>treatment</kwd><kwd>practicing physicians</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">World allergy organization anaphylaxis guidance 2020 / V. Cardona, I. J. Ansotegui, M. Ebisawa [et al.] // World Allergy Organization Journal. — 2020. — Vol. 13, № 10. — DOI: 10.1016/j.waojou.2020.100472.</mixed-citation><mixed-citation xml:lang="en">World allergy organization anaphylaxis guidance 2020 / V. Cardona, I. J. Ansotegui, M. Ebisawa [et al.] // World Allergy Organization Journal. — 2020. — Vol. 13, № 10. — DOI: 10.1016/j.waojou.2020.100472.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Anaphylaxis : a 2023 practice parameter update / D. B. K. Golden, Ju. Wang, S. Waserman [et al.] // Annals of Allergy, Asthma &amp; Immunology. — 2024. — Vol. 132, № 2. — P. 124—176.</mixed-citation><mixed-citation xml:lang="en">Anaphylaxis : a 2023 practice parameter update / D. B. K. Golden, Ju. Wang, S. Waserman [et al.] // Annals of Allergy, Asthma &amp; Immunology. — 2024. — Vol. 132, № 2. — P. 124—176.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Conner, J. E. Approach to idiopathic anaphylaxis in adolescents / J. E. Conner, J. A. Steinberg // Medical Clinics of North America. — 2024. — Vol. 108, № 1. — P. 123—155.</mixed-citation><mixed-citation xml:lang="en">Conner, J. E. Approach to idiopathic anaphylaxis in adolescents / J. E. Conner, J. A. Steinberg // Medical Clinics of North America. — 2024. — Vol. 108, № 1. — P. 123—155.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Webb, L. M. Anaphylaxis : a review of 601 cases / L. M. Webb, P. Lieberman // Annals of Allergy, Asthma &amp; Immunology. — 2006. — Vol. 97. — P. 39—43.</mixed-citation><mixed-citation xml:lang="en">Webb, L. M. Anaphylaxis : a review of 601 cases / L. M. Webb, P. Lieberman // Annals of Allergy, Asthma &amp; Immunology. — 2006. — Vol. 97. — P. 39—43.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Disparities in pediatric anaphylaxis triggers and management across Asia / A. S. Y. Leung, E. H. Tham, P. Pacharn [et al.] // Allergy. — 2024. — Vol. 79. — P. 1317—1328.</mixed-citation><mixed-citation xml:lang="en">Disparities in pediatric anaphylaxis triggers and management across Asia / A. S. Y. Leung, E. H. Tham, P. Pacharn [et al.] // Allergy. — 2024. — Vol. 79. — P. 1317—1328.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hidden and rare food allergens in pediatric age / L. Tomei, A. Muraro, M. Giovannini [et al.] // Nutrients. — 2023. — Vol. 15, № 6. — DOI: 10.3390/nu15061386.</mixed-citation><mixed-citation xml:lang="en">Hidden and rare food allergens in pediatric age / L. Tomei, A. Muraro, M. Giovannini [et al.] // Nutrients. — 2023. — Vol. 15, № 6. — DOI: 10.3390/nu15061386.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Melethil, S. Rare causes of pediatric anaphylaxis due to obscure allergens / S. Melethil, E. Yousef // Front Allergy. — 2024. — Vol. 26, № 5. — DOI: 10.3389/FALGY.2024.1456100.</mixed-citation><mixed-citation xml:lang="en">Melethil, S. Rare causes of pediatric anaphylaxis due to obscure allergens / S. Melethil, E. Yousef // Front Allergy. — 2024. — Vol. 26, № 5. — DOI: 10.3389/FALGY.2024.1456100.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Василевский, И. В. Идиопатическая анафилаксия в реальной врачебной практике / И. В. Василевский, А. П. Рубан // Медицинские новости. — 2024. —№ 11.— С. 16—20.</mixed-citation><mixed-citation xml:lang="en">Василевский, И. В. Идиопатическая анафилаксия в реальной врачебной практике / И. В. Василевский, А. П. Рубан // Медицинские новости. — 2024. —№ 11.— С. 16—20.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Рубан, А. П. Анафилаксия в практике педиатра, фокус на диагностику / А. П. Рубан // Рецепт. — 2022. — Т. 25, № 5. — С. 702—711.</mixed-citation><mixed-citation xml:lang="en">Рубан, А. П. Анафилаксия в практике педиатра, фокус на диагностику / А. П. Рубан // Рецепт. — 2022. — Т. 25, № 5. — С. 702—711.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Пищевая аллергия. Диагностика, лечение и профилактика : учеб. пособие / Т. С. Лепешкова, Е. К. Бельтюков, В. В. Наумова [и др.] ; Министерство здравоохранения Российской Федерации, Уральский государственный медицинский университет. — Екатеринбург : УГМУ, 2021. — 113 с.</mixed-citation><mixed-citation xml:lang="en">Пищевая аллергия. Диагностика, лечение и профилактика : учеб. пособие / Т. С. Лепешкова, Е. К. Бельтюков, В. В. Наумова [и др.] ; Министерство здравоохранения Российской Федерации, Уральский государственный медицинский университет. — Екатеринбург : УГМУ, 2021. — 113 с.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Adult IgE-mediated food allergy is on the rise : a review of phenotypes, pathophysiologicmechanisms, diagnosis, and advances in management / C. Unhapipatpong, N. Julanon, Th. Krikeerati [et al.] // Asian Pacific Journal of Allergy and Immunology. — 2022. — Vol. 40. — P. 308—320.</mixed-citation><mixed-citation xml:lang="en">Adult IgE-mediated food allergy is on the rise : a review of phenotypes, pathophysiologicmechanisms, diagnosis, and advances in management / C. Unhapipatpong, N. Julanon, Th. Krikeerati [et al.] // Asian Pacific Journal of Allergy and Immunology. — 2022. — Vol. 40. — P. 308—320.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Exercise-food challenge test in patients with wheat-dependent exercise-induced anaphylaxis / W. Srisuwatchari, M. Sompornrattanaphan, O. Jirapongsananuruk [et al.] // Asian Pacific Journal of Allergy and Immunology. — 2024. — Vol. 42. — P. 43—49.</mixed-citation><mixed-citation xml:lang="en">Exercise-food challenge test in patients with wheat-dependent exercise-induced anaphylaxis / W. Srisuwatchari, M. Sompornrattanaphan, O. Jirapongsananuruk [et al.] // Asian Pacific Journal of Allergy and Immunology. — 2024. — Vol. 42. — P. 43—49.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Du Toit, G. Food-dependent exercise-induced anaphylaxis in childhood / G. Du Toit // Pediatric Allergy and Immunology. — 2007. — Vol. 18. — P. 455—463.</mixed-citation><mixed-citation xml:lang="en">Du Toit, G. Food-dependent exercise-induced anaphylaxis in childhood / G. Du Toit // Pediatric Allergy and Immunology. — 2007. — Vol. 18. — P. 455—463.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Пампура, А. Н. Анафилаксия, индуцированная физической нагрузкой / А. Н. Пампура, Н. В. Есакова, Е. А. Филиппова // Вопросы детской диетологии. — 2024. — Т. 22, № 4. — С. 20—26.</mixed-citation><mixed-citation xml:lang="en">Пампура, А. Н. Анафилаксия, индуцированная физической нагрузкой / А. Н. Пампура, Н. В. Есакова, Е. А. Филиппова // Вопросы детской диетологии. — 2024. — Т. 22, № 4. — С. 20—26.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Feldweg, A. M. Exercise-induced anaphylaxis / A. M. Feldweg // Immunology and Allergy Clinics of North America. — 2015. — Vol. 35. — P. 261—275.</mixed-citation><mixed-citation xml:lang="en">Feldweg, A. M. Exercise-induced anaphylaxis / A. M. Feldweg // Immunology and Allergy Clinics of North America. — 2015. — Vol. 35. — P. 261—275.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Пампура, А. Н. Анафилаксия у детей / А. Н. Пампура, Н. В. Есакова. — М. : Медпрактика-М, 2020. — 368 с.</mixed-citation><mixed-citation xml:lang="en">Пампура, А. Н. Анафилаксия у детей / А. Н. Пампура, Н. В. Есакова. — М. : Медпрактика-М, 2020. — 368 с.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">The natural history of exercise-induced anaphylaxis : survey results from a 10-year follow-up study / N. A. Shadick, M. H. Liang, A. J. Partridge [et al.] // Journal of Allergy and Clinical Immunology. — 1999. — Vol. 104. — P. 123—127.</mixed-citation><mixed-citation xml:lang="en">The natural history of exercise-induced anaphylaxis : survey results from a 10-year follow-up study / N. A. Shadick, M. H. Liang, A. J. Partridge [et al.] // Journal of Allergy and Clinical Immunology. — 1999. — Vol. 104. — P. 123—127.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz, H. J. Elevated serum tryptase in exercise-induced anaphylaxis / H. J. Schwartz // Journal of Allergy and Clinical Immunology. — 1995. — Vol. 95, iss. 4. — P. 917—919.</mixed-citation><mixed-citation xml:lang="en">Schwartz, H. J. Elevated serum tryptase in exercise-induced anaphylaxis / H. J. Schwartz // Journal of Allergy and Clinical Immunology. — 1995. — Vol. 95, iss. 4. — P. 917—919.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Food-dependent exercise-induced anaphylaxis: possible impact of increased basophil histamine releasability in hyperosmolar conditions / W. Barg, A. Wolanczyk-Medrala, A. Obojski [et al.] // Journal of Allergy and Clinical Immunology. — 2008. — Vol. 18. — P. 312—315.</mixed-citation><mixed-citation xml:lang="en">Food-dependent exercise-induced anaphylaxis: possible impact of increased basophil histamine releasability in hyperosmolar conditions / W. Barg, A. Wolanczyk-Medrala, A. Obojski [et al.] // Journal of Allergy and Clinical Immunology. — 2008. — Vol. 18. — P. 312—315.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Exercise and aspirin increase levels of circulating gliadin peptides in patients with wheat-dependent exercise-induced anaphylaxis / H. Matsuo, K. Morimoto, T. Akaki [et al.] // Clinical &amp; Experimental Allergy. — 2005. — Vol. 35. — P. 461—466.</mixed-citation><mixed-citation xml:lang="en">Exercise and aspirin increase levels of circulating gliadin peptides in patients with wheat-dependent exercise-induced anaphylaxis / H. Matsuo, K. Morimoto, T. Akaki [et al.] // Clinical &amp; Experimental Allergy. — 2005. — Vol. 35. — P. 461—466.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Suto, N. Expression induced by interleukin-6 of tissue-type transglutaminase in human hepatoblastoma HepG2 cells / N. Suto, K. Ikura, R. Sasaki // Journal of Biological Chemistry. — 1993. — Vol. 268. — P. 7469—7473.</mixed-citation><mixed-citation xml:lang="en">Suto, N. Expression induced by interleukin-6 of tissue-type transglutaminase in human hepatoblastoma HepG2 cells / N. Suto, K. Ikura, R. Sasaki // Journal of Biological Chemistry. — 1993. — Vol. 268. — P. 7469—7473.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Geller, M. Diagnostic and therapeutic approach in patients with exercise-induced anaphylaxis / M. Geller // Current Treatment Options in Allergy. — 2016. — Vol. 3. — P. 181—188.</mixed-citation><mixed-citation xml:lang="en">Geller, M. Diagnostic and therapeutic approach in patients with exercise-induced anaphylaxis / M. Geller // Current Treatment Options in Allergy. — 2016. — Vol. 3. — P. 181—188.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Wheat-dependent exercise-induced anaphylaxis / K. A. Scherf, K. Brockow, T. Biedermann [et al.] // Clinical &amp; Experimental Allergy. — 2016. — Vol. 46. — P. 10—20.</mixed-citation><mixed-citation xml:lang="en">Wheat-dependent exercise-induced anaphylaxis / K. A. Scherf, K. Brockow, T. Biedermann [et al.] // Clinical &amp; Experimental Allergy. — 2016. — Vol. 46. — P. 10—20.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Benito-Garcia, F. Diagnosis and prevention of food-dependent exercise-induced anaphylaxis / F. Benito-Garcia, I. J. Ansotegui, M. Morais-Almeida // Expert Review of Clinical Immunology. — 2019. — Vol. 15. — P. 849—856.</mixed-citation><mixed-citation xml:lang="en">Benito-Garcia, F. Diagnosis and prevention of food-dependent exercise-induced anaphylaxis / F. Benito-Garcia, I. J. Ansotegui, M. Morais-Almeida // Expert Review of Clinical Immunology. — 2019. — Vol. 15. — P. 849—856.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Пищевая аллергия к белкам пшеницы. Трудности диагностики и лечения / Е. А. Вишнева, Л. С. Намазова-Баранова, С. Г. Макарова [и др.] // Педиатрическая фармакология. — 2015. — Т. 12, № 4. — С. 429—434.</mixed-citation><mixed-citation xml:lang="en">Пищевая аллергия к белкам пшеницы. Трудности диагностики и лечения / Е. А. Вишнева, Л. С. Намазова-Баранова, С. Г. Макарова [и др.] // Педиатрическая фармакология. — 2015. — Т. 12, № 4. — С. 429—434.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Rye gamma-70 and gamma-35 secalins and barley gamma-3 hordein cross-react with omega-5 gliadin, a major allergen in wheat-dependent, exercise-induced anaphylaxis / K. Palosuo, H. Alenius, E. Varjonen [et al.] // Clinical &amp; Experimental Allergy. — 2001. — Vol. 31, № 3. — P. 466—473.</mixed-citation><mixed-citation xml:lang="en">Rye gamma-70 and gamma-35 secalins and barley gamma-3 hordein cross-react with omega-5 gliadin, a major allergen in wheat-dependent, exercise-induced anaphylaxis / K. Palosuo, H. Alenius, E. Varjonen [et al.] // Clinical &amp; Experimental Allergy. — 2001. — Vol. 31, № 3. — P. 466—473.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Identification of allergens for food-dependent exercise-induced anaphylaxis to shrimp / S. Akimoto, T. Yokooji, R. Ogino [et al.] // Scientific Reports. — 2021. — Vol. 11. — DOI: 10.1038/s41598-021-84752-2.</mixed-citation><mixed-citation xml:lang="en">Identification of allergens for food-dependent exercise-induced anaphylaxis to shrimp / S. Akimoto, T. Yokooji, R. Ogino [et al.] // Scientific Reports. — 2021. — Vol. 11. — DOI: 10.1038/s41598-021-84752-2.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kraft M. Wheat anaphylaxis in adults differs from reactions to other types of food / M. Kraft, S. Dolle-Bierke, J.-M. Renaudin [et al.] // The Journal of Allergy and Clinical Immunology: in Practice. — 2021. — Vol. 9. — DOI: 10.1016/j.jaip.2021.03.037.</mixed-citation><mixed-citation xml:lang="en">Kraft M. Wheat anaphylaxis in adults differs from reactions to other types of food / M. Kraft, S. Dolle-Bierke, J.-M. Renaudin [et al.] // The Journal of Allergy and Clinical Immunology: in Practice. — 2021. — Vol. 9. — DOI: 10.1016/j.jaip.2021.03.037.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Об утверждении клинического протокола «Оказание экстренной и неотложной медицинской помощи пациентам детского возраста»: постановление Минздрава Беларуси от 17 августа 2023 г. № 118 // Национальный правовой Интернет-портал Республики Беларусь. — URL: https://pravo.by/document/?guid=12551&amp;p0=W22340389p (дата обращения: 21.09.2023).</mixed-citation><mixed-citation xml:lang="en">Об утверждении клинического протокола «Оказание экстренной и неотложной медицинской помощи пациентам детского возраста»: постановление Минздрава Беларуси от 17 августа 2023 г. № 118 // Национальный правовой Интернет-портал Республики Беларусь. — URL: https://pravo.by/document/?guid=12551&amp;p0=W22340389p (дата обращения: 21.09.2023).</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Feldweg, A. M. Food-Dependent, exercise-induced anaphylaxis: diagnosis and management in the outpatient setting / A. M. Feldweg // The Journal of Allergy and Clinical Immunology: in Practice. — 2017. — Vol. 5. — P. 283—288.</mixed-citation><mixed-citation xml:lang="en">Feldweg, A. M. Food-Dependent, exercise-induced anaphylaxis: diagnosis and management in the outpatient setting / A. M. Feldweg // The Journal of Allergy and Clinical Immunology: in Practice. — 2017. — Vol. 5. — P. 283—288.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Foong, R. X. Food-dependent exercise-induced anaphylaxis / R. X. Foong, M. Giovannini, G. du Toit // Current Opinion in Allergy and Clinical Immunology. — 2019. — Vol. 19. — P. 224—228.</mixed-citation><mixed-citation xml:lang="en">Foong, R. X. Food-dependent exercise-induced anaphylaxis / R. X. Foong, M. Giovannini, G. du Toit // Current Opinion in Allergy and Clinical Immunology. — 2019. — Vol. 19. — P. 224—228.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Alpha-Gal Syndrome in Children: Peculiarities of a «Tick-Borne» Allergic Disease / F. Saretta, M. Giovannini, F. Mori [et al.] // Frontiers in Pediatrics. — 2021. — Vol. 9. — DOI: 10.3389/fped.2021.801753.</mixed-citation><mixed-citation xml:lang="en">Alpha-Gal Syndrome in Children: Peculiarities of a «Tick-Borne» Allergic Disease / F. Saretta, M. Giovannini, F. Mori [et al.] // Frontiers in Pediatrics. — 2021. — Vol. 9. — DOI: 10.3389/fped.2021.801753.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Peptidomics of an in vitro digested α-Gal carrying protein revealed IgE-reactive peptides / D. Apostolovic, M. Krstic, J. Mihailovic [et al.] // Scientific Reports. — 2017. — Vol. 7. — DOI: 10.1038/s41598017-05355-4.</mixed-citation><mixed-citation xml:lang="en">Peptidomics of an in vitro digested α-Gal carrying protein revealed IgE-reactive peptides / D. Apostolovic, M. Krstic, J. Mihailovic [et al.] // Scientific Reports. — 2017. — Vol. 7. — DOI: 10.1038/s41598017-05355-4.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">The alpha-gal syndrome: new insights into the tick-host conflict and cooperation / J. de la Fuente, I. Pacheco, M. Villar, A. Cabezas-Cruz // Parasites Vectors. — 2019. — Vol. 12. — P. 154—158.</mixed-citation><mixed-citation xml:lang="en">The alpha-gal syndrome: new insights into the tick-host conflict and cooperation / J. de la Fuente, I. Pacheco, M. Villar, A. Cabezas-Cruz // Parasites Vectors. — 2019. — Vol. 12. — P. 154—158.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Cutaneous exposure to clinically relevant lone star ticks promotes IgE production and hypersensitivity through CD4+T celland MyD88-dependent pathways in mice / J. L. Chandrasekhar, K. M. Cox, W. M. Loo [et al.] // Journal of Immunology. — 2019. — Vol. 203. — P. 813—824.</mixed-citation><mixed-citation xml:lang="en">Cutaneous exposure to clinically relevant lone star ticks promotes IgE production and hypersensitivity through CD4+T celland MyD88-dependent pathways in mice / J. L. Chandrasekhar, K. M. Cox, W. M. Loo [et al.] // Journal of Immunology. — 2019. — Vol. 203. — P. 813—824.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Pattanaik D. The changing face of anaphylaxis in adults and adolescents / D. Pattanaik, Ph. Lieberman, J. Lieberman [et al.] // Annals of Allergy, Asthma &amp; Immunology. — 2018. — Vol. 121. — P. 594—597.</mixed-citation><mixed-citation xml:lang="en">Pattanaik D. The changing face of anaphylaxis in adults and adolescents / D. Pattanaik, Ph. Lieberman, J. Lieberman [et al.] // Annals of Allergy, Asthma &amp; Immunology. — 2018. — Vol. 121. — P. 594—597.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Galactose-alpha-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children / J. L. Kennedy, A. P. Stallings, T. A. E. Platts-Mills [et al.] // Pediatrics. — 2013. — Vol. 131. — DOI: 10.1542/ peds.2012-2585.</mixed-citation><mixed-citation xml:lang="en">Galactose-alpha-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children / J. L. Kennedy, A. P. Stallings, T. A. E. Platts-Mills [et al.] // Pediatrics. — 2013. — Vol. 131. — DOI: 10.1542/ peds.2012-2585.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Investigation into the alpha-gal syndrome: characteristics of 261 children and adults reporting red meat allergy / J. M. Wilson, Al. J. Schuyler, L. Workman [et al.] // The Journal of Allergy and Clinical Immunology: in Practice. — 2019. — Vol. 7. — P. 2348—2358.</mixed-citation><mixed-citation xml:lang="en">Investigation into the alpha-gal syndrome: characteristics of 261 children and adults reporting red meat allergy / J. M. Wilson, Al. J. Schuyler, L. Workman [et al.] // The Journal of Allergy and Clinical Immunology: in Practice. — 2019. — Vol. 7. — P. 2348—2358.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Environmental and molecular drivers of the α-gal syndrome / A. Cabezas-Cruz, A. Hodzic, P. RomanCarrasco [et al.] // Frontiers in Immunology. — 2019. — Vol. 10. — DOI: 10.3389/fimmu.2019.01210.</mixed-citation><mixed-citation xml:lang="en">Environmental and molecular drivers of the α-gal syndrome / A. Cabezas-Cruz, A. Hodzic, P. RomanCarrasco [et al.] // Frontiers in Immunology. — 2019. — Vol. 10. — DOI: 10.3389/fimmu.2019.01210.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Commins, S. P. Diagnosis &amp; management of alpha-gal syndrome: lessons from 2,500 patients / S. P. Commins // Expert Review of Clinical Immunology. — 2020. — Vol. 16. — P. 667—677.</mixed-citation><mixed-citation xml:lang="en">Commins, S. P. Diagnosis &amp; management of alpha-gal syndrome: lessons from 2,500 patients / S. P. Commins // Expert Review of Clinical Immunology. — 2020. — Vol. 16. — P. 667—677.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Idiopathic anaphylaxis / M. B. Bilo, M. Martini, Ch. Tontini [et al.] // Clinical &amp; Experimental Allergy. — 2019. — Vol. 49. — P. 942—952.</mixed-citation><mixed-citation xml:lang="en">Idiopathic anaphylaxis / M. B. Bilo, M. Martini, Ch. Tontini [et al.] // Clinical &amp; Experimental Allergy. — 2019. — Vol. 49. — P. 942—952.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Fernandez, J. Management of idiopathic anaphylaxis: when is bone marrow examination essential / J. Fernandez, C. Akin // Current Treatment Options in Allergy. — 2014. — Vol. 1. — P. 221—231.</mixed-citation><mixed-citation xml:lang="en">Fernandez, J. Management of idiopathic anaphylaxis: when is bone marrow examination essential / J. Fernandez, C. Akin // Current Treatment Options in Allergy. — 2014. — Vol. 1. — P. 221—231.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Greenberger, P. A. Idiopathic anaphylaxis / P. A. Greenberger, Ph. Lieberman // Immunology and Allergy Clinics of North America. — 2007. — Vol. 27. — P. 273—293.</mixed-citation><mixed-citation xml:lang="en">Greenberger, P. A. Idiopathic anaphylaxis / P. A. Greenberger, Ph. Lieberman // Immunology and Allergy Clinics of North America. — 2007. — Vol. 27. — P. 273—293.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Commins, S. P. Invited commentary: alpha-gal allergy: tip of the iceberg to a pivotal immune response / S. P. Commins // Current Allergy and Asthma Reports. — 2016. — Vol. 16. — DOI: 10.1007/s11882016-0641-6.</mixed-citation><mixed-citation xml:lang="en">Commins, S. P. Invited commentary: alpha-gal allergy: tip of the iceberg to a pivotal immune response / S. P. Commins // Current Allergy and Asthma Reports. — 2016. — Vol. 16. — DOI: 10.1007/s11882016-0641-6.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Commins, S. P. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose alpha-1,3-galactose / S. P. Commins, Sh. M. Satinover, J. Hosen [et al.] // The Journal of Allergy and Clinical Immunology. — 2009. — Vol. 123. — P. 426—433.</mixed-citation><mixed-citation xml:lang="en">Commins, S. P. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose alpha-1,3-galactose / S. P. Commins, Sh. M. Satinover, J. Hosen [et al.] // The Journal of Allergy and Clinical Immunology. — 2009. — Vol. 123. — P. 426—433.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">IgE to galactose-α-1,3-galactose wanes over time in patients who avoid tick bites / M. S. Kim, M. D. Straesser, B. Keshavarz [et al.] // The Journal of Allergy &amp; Clinical Immunology: In Practice. — 2020. — Vol. 8. — P. 364—367.</mixed-citation><mixed-citation xml:lang="en">IgE to galactose-α-1,3-galactose wanes over time in patients who avoid tick bites / M. S. Kim, M. D. Straesser, B. Keshavarz [et al.] // The Journal of Allergy &amp; Clinical Immunology: In Practice. — 2020. — Vol. 8. — P. 364—367.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Anaphylaxis from ingestion of mites: pancake anaphylaxis / M. Sanchez-Borges, R. S. Chacon, A. Capriles-Hulett [et al.] // The Journal of Allergy and Clinical Immunology. — 2013. — Vol. 131. — P. 31—35.</mixed-citation><mixed-citation xml:lang="en">Anaphylaxis from ingestion of mites: pancake anaphylaxis / M. Sanchez-Borges, R. S. Chacon, A. Capriles-Hulett [et al.] // The Journal of Allergy and Clinical Immunology. — 2013. — Vol. 131. — P. 31—35.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Kamizono, S. A case of oral mite anphylaxis in which basophil activation test was useful for diagnosis / S. Kamizono, T. Fujimoto // Arerugi (Japan). — 2018. — Vol. 67. — P. 219—223.</mixed-citation><mixed-citation xml:lang="en">Kamizono, S. A case of oral mite anphylaxis in which basophil activation test was useful for diagnosis / S. Kamizono, T. Fujimoto // Arerugi (Japan). — 2018. — Vol. 67. — P. 219—223.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Василевский, И. В. Профилактика и лечение пищевой аллергии / И. В. Василевский // Медицинские знания. — 2016. — № 4. — С. 4—11.</mixed-citation><mixed-citation xml:lang="en">Василевский, И. В. Профилактика и лечение пищевой аллергии / И. В. Василевский // Медицинские знания. — 2016. — № 4. — С. 4—11.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Титова, Н. Д. Пищевые добавки как алиментарные аллергены / Н. Д. Титова // Иммунопатология, аллергология, инфектология. — 2008. — № 2. — С. 41—46.</mixed-citation><mixed-citation xml:lang="en">Титова, Н. Д. Пищевые добавки как алиментарные аллергены / Н. Д. Титова // Иммунопатология, аллергология, инфектология. — 2008. — № 2. — С. 41—46.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Food hypersensitivity in children: clinical aspects and distribution of allergens / F. Rance, G. Kanny, G. Dutau, D. A. Moneret-Vautrin // Pediatric Allergy and Immunology. — 1999. — Vol. 10. — P. 33—38.</mixed-citation><mixed-citation xml:lang="en">Food hypersensitivity in children: clinical aspects and distribution of allergens / F. Rance, G. Kanny, G. Dutau, D. A. Moneret-Vautrin // Pediatric Allergy and Immunology. — 1999. — Vol. 10. — P. 33—38.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Characterization of potential allergens in fenugreek (Trigonellafoenum-graecum) using patient sera and MS-based proteomic analysis / C. K. Faeste, U. Christians, E. Egaas, K. R. Jonscher // Journal of Proteomics. — 2010. — Vol. 73. — P. 1321—1333.</mixed-citation><mixed-citation xml:lang="en">Characterization of potential allergens in fenugreek (Trigonellafoenum-graecum) using patient sera and MS-based proteomic analysis / C. K. Faeste, U. Christians, E. Egaas, K. R. Jonscher // Journal of Proteomics. — 2010. — Vol. 73. — P. 1321—1333.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Sodium metabisulphite allergy with multiple food and drug hypersensitivities in a five-year-old child : a case report and literature review / G.Vitaliti, F. Guglielmo, L. Giunta, [et al.] // Allergol Immunopathol (Madr). — 2015. — Vol. 43. — P. 106—108.</mixed-citation><mixed-citation xml:lang="en">Sodium metabisulphite allergy with multiple food and drug hypersensitivities in a five-year-old child : a case report and literature review / G.Vitaliti, F. Guglielmo, L. Giunta, [et al.] // Allergol Immunopathol (Madr). — 2015. — Vol. 43. — P. 106—108.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Harada, K. M230 the plot thickens: fruit pectin and food allergy / K. Harada, S. Zhang, S. Sicherer // Annals of Allergy, Asthma &amp; Immunology. — 2021. — Vol. 127. — DOI: 10.1016/j.anai.2021.08.359.</mixed-citation><mixed-citation xml:lang="en">Harada, K. M230 the plot thickens: fruit pectin and food allergy / K. Harada, S. Zhang, S. Sicherer // Annals of Allergy, Asthma &amp; Immunology. — 2021. — Vol. 127. — DOI: 10.1016/j.anai.2021.08.359.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Wang, J. Anaphylaxis following ingestion of candy fruit chews / J. Wang, S. H. Sicherer // Annals of Allergy, Asthma &amp; Immunology. — 2005. — Vol. 94. — P. 530—533.</mixed-citation><mixed-citation xml:lang="en">Wang, J. Anaphylaxis following ingestion of candy fruit chews / J. Wang, S. H. Sicherer // Annals of Allergy, Asthma &amp; Immunology. — 2005. — Vol. 94. — P. 530—533.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Романова, И. В. Тест активации базофилов: технология метода и его применение в клинической практике / И. В. Романова, А. Е. Гончаров // Иммунопатология, аллергология, инфектология. — 2018. — № 1. — С. 26—34.</mixed-citation><mixed-citation xml:lang="en">Романова, И. В. Тест активации базофилов: технология метода и его применение в клинической практике / И. В. Романова, А. Е. Гончаров // Иммунопатология, аллергология, инфектология. — 2018. — № 1. — С. 26—34.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Рубан, А. П. Актуальные задачи аллергологической помощи детям / А. П. Рубан, А. Е. Гончаров, В. Н. Ростовцев // Вопросы организации и информатизации здравоохранения. — 2022. — Приложение. — С. 214—218.</mixed-citation><mixed-citation xml:lang="en">Рубан, А. П. Актуальные задачи аллергологической помощи детям / А. П. Рубан, А. Е. Гончаров, В. Н. Ростовцев // Вопросы организации и информатизации здравоохранения. — 2022. — Приложение. — С. 214—218.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
