<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">healthcare</journal-id><journal-title-group><journal-title xml:lang="ru">Здравоохранение. Healthcare</journal-title><trans-title-group xml:lang="en"><trans-title>Healthcare</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1027-7218</issn><publisher><publisher-name>Republican Scientific and Practical Center for Medical Technologies, Informatization, Management and Health Economics</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">healthcare-8</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая медицина</subject></subj-group></article-categories><title-group><article-title>Клинические особенности формирующегося синдромаполикистозных яичников в подростковом возрасте</article-title><trans-title-group xml:lang="en"><trans-title>Clinical features of emerging polycystic ovary syndrome in adolescence</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Можейко</surname><given-names>Л. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Mozheiko</surname><given-names>L. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кириллова</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kirillova</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пр. Дзержинского, 83, 220083, г. Минск</p><p>Минск</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Бeлoрусский гoсударствeнный мeдицинский унивeрситeт</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>22</day><month>09</month><year>2025</year></pub-date><volume>1</volume><issue>6</issue><fpage>4</fpage><lpage>9</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Можейко Л.Ф., Кириллова Е.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Можейко Л.Ф., Кириллова Е.Н.</copyright-holder><copyright-holder xml:lang="en">Mozheiko L.F., Kirillova E.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://healthcare.ejournal.by/jour/article/view/8">https://healthcare.ejournal.by/jour/article/view/8</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Изучить характерные клинико-диагностические особенности у девочек-подростков при различных фенотипах формирующегося синдрома поликистозных яичников (СПКЯ).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включены 205 девочек-подростков в возрасте 12-18 лет. Основная группа - 159 девочек с признаками СПКЯ, группа контроля - 46 здоровых девочек. Проведены анкетирование и клиническое обследование.</p></sec><sec><title>Результаты</title><p>Результаты. Наиболее выраженные отклонения в половом развитии выявлены при классическом фенотипе СПКЯ. У девочек с нарушениями, соответствующими указанному фенотипу, в 21% случаев отмечена инверсия развития вторичных половых признаков, в 42% - позднее телархе, в 18,4% - позднее менархе. Сонографическими критериями для формирующегося СПКЯ являются: увеличение объема яичников, наличие эхопозитивной стромы и большого количества фолликулов различного диаметра с эхопозитивной стенкой.</p></sec><sec><title>Заключение</title><p>Заключение. В период становления репродуктивной системы следует учитывать следующие особенности полового развития: нарушение очередности развития вторичных половых признаков, раннее пубархе, раннее или позднее телархе, ранний или поздний возраст менархе. Выявление указанных клинических признаков является основанием для включения таких девочек в группу риска по формированию СПКЯ с целью ранней коррекции нарушений репродуктивной функции на этапе формирования.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. То study the characteristic clinical and diagnostic features in adolescent girls with various phenotypes of theemerging polycystic ovary syndrome.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 205 teenage girls aged 12-18 years. The main group consisted of159 girls with signs of PCOS and 46 healthy girls - the control group. Their questionnaires and clinical examination wereconducted.</p></sec><sec><title>Results</title><p>Results. The most pronounced deviations in sexual development were revealed in the classical PCOS phenotype. Ingirls with disorders corresponding to the specified phenotype, an inversion of the development of secondary sexualcharacteristics was noted in 21 % of cases, in 42% - later telarche, in 18,4 % - later menarche. The sonographic criteriafor the emerging polycystic ovary syndrome are: increased ovarian volume, the presence of an echopositive stroma and alarge number of follicles of various diameters with an echopositive wall.</p></sec><sec><title>Conclusion</title><p>Conclusion. During the formation of the reproductive system, the following features of sexual development should betaken into account: aberration of the sequence of development of secondary sexual characteristics, early puberty, early orlate telarche, early or late age of menarche. The identification of these clinical signs is the premise for including such girlsinto the PCOS risk group in order to appropriately handle the reproductive function deviations at early stages of theirdevelopment.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром поликистозных яичников</kwd><kwd>клинические признаки</kwd><kwd>девочки-подростки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>polycystic ovary syndrome</kwd><kwd>clinical signs</kwd><kwd>teenage girls correct reproductive disorders at the stage offormation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Можейко Л. Ф. Становление репродуктивной системы у девочек-подростков и коррекция ее нарушений: монография. Минск: БГМУ; 2002. 231 с.</mixed-citation><mixed-citation xml:lang="en">Mozhejko L. F. The formation of the reproductive system in adolescent girls and the correction of its disorders: a monograph. Minsk: BGMU: 2002. 231 s. [(in Russian)]</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Кириллова Е. Н., Генералова А. А. Стимуляция овуляции у женщин с синдромом поликистозных яичников. Мед. журн. 2013; 1: 139-41. EDN: RSKQRB</mixed-citation><mixed-citation xml:lang="en">Kirillova E. N., Generalova A. A. Stimulation of ovulation in women with polycystic ovary syndrome. Med. zhurn. 2013; 1: 139—41. [(in Russian)]</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Солнцева А. В., Вязова Л. С. Детское ожирение и пищевое поведение. Белорус. гос. мед. ун-т. Минск: РНМБ; 2018. 100 с.</mixed-citation><mixed-citation xml:lang="en">Solnceva A. V., Vyazova L. S. Childhood obesity and eating behavior. Belorus. gos. med. un-t. Minsk: RNMB; 2018. 100 s. [(in Russian)]</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Гуркин Ю. А. Детская и подростковая гинекология: руководство для врачей. М.: Медицинское информационное агентство; 2009. 696 с. EDN: QLTENL</mixed-citation><mixed-citation xml:lang="en">Gurkin Yu. A. Pediatric and adolescent gynecology: A guide for doctors. M.: Medicinskoe informacionnoe agentstvo; 2009. 696 s. [(in Russian)]</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Можейко Л. Ф. Синдром поликистозных яичников: современный взгляд на проблему. Репродуктивное здоровье. Восточная Европа. 2022; 3: 390-403. EDN: CFIUCK</mixed-citation><mixed-citation xml:lang="en">Mozhejko L. F. Polycystic ovary syndrome: a modern view of the problem. Reproduktivnoe zdorov´e. Vostochnaya Evropa. 2022; 3: 390—403. [(in Russian)].</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Miller W. L., Тее М. К. The post-translational regulation of 17,20 lyase activity. Mol. Cell Endocrinol. 201S; 408 (8): 99-106.</mixed-citation><mixed-citation xml:lang="en">Miller W. L., Tee M. K. The post-translational regulation of 17,20 lyase activity. Mol. Cell Endocrinol. 2015; 408 (8): 99—106.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Можейко Л. Ф. Этиопатогенез, диагностика и лечение синдрома поликистозных яичников в подростковом возрасте. Репродуктивное здоровье. Восточная Европа. 2023; 4: 321-30. EDN: UNBEBL</mixed-citation><mixed-citation xml:lang="en">Mozhejko L. F. Etiopathogenesis, diagnosis and treatment of polycystic ovary syndrome in adolescence. Reproduktivnoe zdorov´e. Vostochnaya Evropa. 2023; 4: 321—30. [(in Russian)]</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenfield R. L., Ehrmann D. A., Littlejohn E. E. Adolescent polycystic ovary syndrome due to functional ovarian hyperandrogenism persists into adulthood. J. Clin. Endocrinol. Metab. 201S; 100 (4): 1S37-43.</mixed-citation><mixed-citation xml:lang="en">Rosenfield R. L., Ehrmann D. A., Littlejohn E. E. Adolescent polycystic ovary syndrome due to functional ovarian hyperandrogenism persists into adulthood. J. Clin. Endocrinol. Metab. 2015; 100 (4): 1537—43.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Villarroel C., Lopez Р., Merino P. M. Hirsutism and oligomenorrhea are appropriate screening criteria for polycystic ovary syndrome in adolescents. Gynecol. Endocrinol. 201S; 31 (8): 62S-9.</mixed-citation><mixed-citation xml:lang="en">Villarroel C., Lopez P., Merino P. M. Hirsutism and oligomenorrhea are appropriate screening criteria for polycystic ovary syndrome in adolescents. Gynecol. Endocrinol. 2015; 31 (8): 625—9.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Pertil. Steril. 2004; 81 (1): 19-2S.</mixed-citation><mixed-citation xml:lang="en">Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil. Steril. 2004; 81 (1): 19—25.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lizneva D., Suturina L., Walker W. et al. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil. Steril. 2016; 106 (I): 6-IS. EDN: XFGSTN</mixed-citation><mixed-citation xml:lang="en">Lizneva D., Suturina L., Walker W. et al. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil. Steril. 2016; 106 (1): 6—15.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
