Clinical features of meningococcal infection in infants (clinical case)
https://doi.org/10.65249/1027-7218-2025-12-75-80
Abstract
Objective. To analyze a clinical case of generalized meningococcal infection in an infant.
Materials and methods. We studied and systematized anamnestic data, the results of clinical, laboratory, instrumental studies, the peculiarities of therapy for a 4-month-old child who was in a hospital with a generalized form of meningococcal infection.
Results. The authors of the work describe a clinical case of meningococcal infection in a baby, which was complicated by sepsis, infectious-toxic shock, disseminated intravascular coagulation syndrome. The course of this infection led to the development of widespread thrombosis of the vessels of the limbs, multiple organ dysfunction syndrome. The article presents the features of the course of the disease, the rapid development of infection, analyzed the provision of medical care at various stages, the treatment that the child received, including antibacterial, symptomatic therapy, mechanical ventilation, surgical treatment of complications.
Conclusion. Severe forms of meningococcal infections are manifested by a sudden onset, a rapid increase in symptoms such as fever, intoxication, and the development of disseminated intravascular coagulation syndrome. Difficulties in diagnosis, rapid involvement of vital organs and systems in the pathological process determine the complexity of treatment and the need for a multidisciplinary approach to the treatment of such patients.
About the Authors
E. AsiryanБеларусь
T. Barilko
Беларусь
N. Skaskevich
Беларусь
References
1. Dmitrieva T.G., Kozhukhova Zh.V., Agaeva L.Z. A clinical case of a rare form of meningococcal infection in a young child. Infektsionnye bolezni: novosti, mneniya, obuchenie. 2025; 14(1): 103–107. (in Russian)
2. Caugant D.A., Maiden M.C.J. Meningococcal carriage and disease – population biology and evolution. Vaccine. 2009; 27(4): 64–70.
3. Masuoka S., Miyazaki O., Takahashi H., et al. Predisposing conditions for bacterial meningitis in children: what radiologists need to know. Jpn J Radiol. 2021; 40(1): 1–18.
4. Davila S., Wright V.J., Khor C.C., et al. Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nat Genet. 2010; 42: 772–776.
5. Caesar J.J.E., Lavender H., Ward P.N., et al. Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility. eLife. 2014; 3. doi: 10.7554/eLife.04008.
6. Bush L.M., Vazquez-Pertejo M.T. Meningococcal infections. Spravochnik MSD. Available at: https://www.msdmanuals.com/ru/home/инфекции/менингококковые-инфекции/менингококковые-инфекции (accessed: 01.09.2024). (in Russian)
7. Vermont C.L., de Groot R., Hazelzet J.A. Bench-to-bedside review: genetic influences on meningococcal disease. Crit Care. 2002; 6(1): 60–65.
8. Semenov V.M. Infectious diseases. Vitebsk; 2020. 372. (in Russian)
9. Immunoprophylaxis of meningococcal infection in children. SP Navigator. – Available at: https://spnavigator.ru/document/c8fcaea7-d840-4229-86ee-53ebb51e5fc9 (accessed: 23.10.2025). (in Russian)
10. Yehya A., Ezzeddine Z., Chakkour M., et al. The intricacies of Acinetobacter baumannii. Front Microbiol. 2025; 16. doi: 10.3389/ fmicb.2025.1565965.
Review
For citations:
Asiryan E., Barilko T., Skaskevich N. Clinical features of meningococcal infection in infants (clinical case). Healthcare. 2025;(12):75-80. (In Russ.) https://doi.org/10.65249/1027-7218-2025-12-75-80
JATS XML
