Features of immune reconstitution in patients after allogeneic hematopoietic stem cell transplantation
Abstract
Immune reconstitution after allogeneic hematopoietic cell transplantation (alloHSCT) is a key factor determining the clinical course after transplantation, since most clinical situations in the post-transplant period, such as acute graft-versus-host disease (аGVHD), infectious complications, and relapse are associated with the speed, quantity, and quality of immune cell reconstitution.
This article presents the results of a study of immune reconstitution in patients after alloHSCT, with an emphasis on the features of immune reconstitution in patients with and without аGVHD.
About the Authors
O. Nechay
Минский научно-практический центр хирургии, трансплантологии и гематологии
Belarus
Belarus
N. Milanovich
Минский научно-практический центр хирургии, трансплантологии и гематологии
Belarus
Belarus
V. Smolnikova
Минский научно-практический центр хирургии, трансплантологии и гематологии
Belarus
Belarus
V. Grinevich
Минский научно-практический центр хирургии, трансплантологии и гематологии
Belarus
Belarus
References
1. Berger, M. Lymphocyte subsets recovery following allogeneic bone marrow transplantation (BMT): CD4+ cell count and transplant-related mortality / M. Berger, O. Figari, B. Bruno // Bone marrow transplantation. — 2008. — Vol. 41, № 1. — P. 55—62.
2. Buckner, J. H. Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases / J. H. Buckner // Nature reviews. Immunology. — 2010. — Vol. 10, № 12. — P. 849—859.
3. Bueger, M. Tissue distribution of human minor histocompatibility antigens. Ubiquitous versus restricted tissue distribution indicates heterogeneity among human cytotoxic T lymphocyte-defined non-MHC antigens / M. Bueger, A. Bakker, J. J. Van Rood // Journal of immunology. — 1992. — Vol. 149, № 5. — P. 1788—1794.
4. Carlson, M. J. In vitro differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations / M. J. Carlson, M. L. West, J. M. Coghill // Blood. — 2009. — Vol. 113, № 6. — P. 1365—1374.
5. Chklovskaia, E. Reconstitution of dendritic and natural killer-cell subsets after allogeneic stem cell transplantation: Effects of endogenous flt3 ligand / E. Chklovskaia, P. Nowbakht, C. Nissen // Blood. — 2004. — Vol. 103, № 10. — P. 3860—3868.
6. Cohen, J. L. CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease / J. L. Cohen, A. Trenado, D. Vasey // J. Exp. Med. — 2002. — Vol. 196, № 3. — P. 401—406.
7. Robb, R. J. The interferon-dependent orchestration of innate and adaptive immunity after transplantation / R. J. Robb, G. R. Hill // Blood. — 2012. — Vol. 119, № 23. — P. 5351—5358.
8. Serody, J. S. T-lymphocyte production of macrophage inflammatory protein-1alpha is critical to the recruitment of CD8(+) T cells to the liver, lung, and spleen during graft-versus-host disease / J. S. Serody, S. E. Burkett, A. Panoskaltsis-Mortari // Blood. — 2000. — Vol. 9, № 9. — P. 2973—2980.
Review
For citations:
Nechay O., Milanovich N., Smolnikova V., Grinevich V. Features of immune reconstitution in patients after allogeneic hematopoietic stem cell transplantation. Healthcare. 2024;(12):27-34. (In Russ.)
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