Dynamics of arterial remodeling parameters in men with grade I and II arterial hypertension
Abstract
Objective. To evaluate the dynamics of the cardio-ankle vascular index (CAVI) and augmentation index (AI) in men with arterial hypertension (AH) of the I and II degrees in the age groups 30—39 and 40—49 years; to identify modifiable and nonmodifiable factors associated with an increase and decrease in CAVI and AI in healthy individuals and in patients with AH 30—49 years old.
Materials and methods. The study involved practically healthy men and men with AH of the I and II degrees aged 30—49 years, who were divided into 6 subgroups: IA — 38 practically healthy men aged 30—39 years; IB — 38 patients with AH of the I degree aged 30—39 years; IC — 21 patients with AH of the II degree aged 30—39 years; IIA — 23 practically healthy men aged 40—49 years; IIB — 35 patients with AH of the I degree aged 40—49 years; IIC — 28 patients with AH of the II degree aged 40—49 years. The CAVI and AI were determined twice on a volumetric sphygmograph VaSera VS-1500 (Japan) with an interval of 13 [12—16] months.
Results. In men from subgroups IA, IB, IIB AI increased with repeated measurement (p = 0.001, p = 0.00001, p = 0.04, respectively). In healthy men the probability of an increase in AI is associated with pulse arterial pressure (β = 0.173, OR — 1.19 (95 % CI (1.08—1.33)), p = 0.0009, AUC = 0.711), non-HDL cholesterol (β = 0.772, OR — 2.16 (95 % CI (1.24—4,05)), p = 0.01, AUC = 0.675) and the presence of excess body weight (β = 1.371, OR — 3.94 (95% CI (1.53—10.84)), p = 0.006, AUC = 0.675). In individuals with AH the increase in AI was associated with obesity (β = 1.462, OR — 4.31 (95 % CI (1.50—13.37)), p = 0.008, AUC = 0.638), but the use of angiotensin II receptor blockers reduced the probability of AI increase (β = -1.117, OR — 0.3273 (95 % CI (0.13—0.76)), p = 0.012, AUC = 0.602).
Conclusion. During the observation period AI increased in healthy individuals aged 30—39 years and in all patients with AH of the I degree, while CAVI did not change in any of the study groups.
The increase in AI in healthy men is associated with the content of non-HDL cholesterol, the level of pulse arterial pressure and excess body weight. The increase in AI over time in patients with hypertension is associated with the presence of obesity. The increase in CAVI was not associated with the studied factors.
About the Authors
T. Levkovich
Гродненский государственный медицинский университет
Belarus
Belarus
T. Pronko
Гродненский государственный медицинский университет
Belarus
Belarus
A. Kapytski
Гродненский государственный медицинский университет
Belarus
Belarus
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Review
For citations:
Levkovich T., Pronko T., Kapytski A. Dynamics of arterial remodeling parameters in men with grade I and II arterial hypertension. Healthcare. 2025;(8):52-65. (In Russ.)
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