Cryptococcal-tuberculous meningoencephalitis in a patient with hiv infection: literature review and personal observation
https://doi.org/10.65249/1027-7218-2025-11-57-64
Abstract
The article presents current literature data on the prevalence and clinical manifestations of a rare pathology — cryptococcosis infection of the central nervous system — meningitis. The article presents a case history of a patient in whom cryptococci and mycobacterium tuberculosis were found in the cerebrospinal fluid at a late stage of HIV infection. The difficulties of differential diagnosis and treatment of this disease are noted.
About the Authors
V. KorovkinBelarus
E. Katibnikova
Belarus
S. Khlopkov
Belarus
A. Martynyuk
Belarus
D. Chistaya
Belarus
References
1. Еlinov N.P., Bosak I.A. Past and present of Cryptococcus neoformans (Sanfelice) Vuillemin (1901) as an object of study of a potentially dangerous pathogen for humans. Problemy medicinskoi mycologii. 2006; 8: 47—51. (in Russian).
2. Fonseca А., Boekhout T., Fell J., et al. Cryptococcus Vuillemin (1901). The yeasts. Amsterdam; 2011: 1665—1741.
3. Mitchell T.G., Perfect J.R. Cryptococcosis in the era of AIDS: 100 years after the discovery of Cryptococcus neoformans. Clin Microbiol Rev. 1995; 8: 515—548.
4. Kaufman C.A., Mandell G.L. (ed.). Atlas gribkovich bolesney. Moscow: GEOTAR-Media; 2010. 240. (in Russian)
5. Bianic T., Boehhout T., Del Poeta M., et al. Special report on 7 International Conferense on Cryptococcus and Cryptococcosis. Mycol Newsletter. 2008: 10—24.
6. Dimitrios P. Invasive mycoses: strategies for effective management. Am J Med. 2012; 125: 25—38.
7. Sergeev A.Yu., Sergeev Yu.V. Resistance factors and immunity in deep mycoses. Immunopathologya, allergologya, infectologya. 2004; 1: 15–20. (in Russian)
8. Romanii, L. Immunity to fungal infections. Nat Rev Immunol. 2011; 11: 275—288.
9. Utsunomia T., Kobayashi M., Herndon D., et al. Effect of glycyrrhizin, an active component of licorice roots, on Candida albicans infection in thermally injured mice. Clin Exp Immunol. 1999; 116(2): 291—298.
10. Vasilyeva N.V. Pathogenicity factors of Cryptococcus neoformans and their role in the pathogenesis of cryptococcosis. SPb.; 2005. 340. (in Russian)
11. Hajjeh R., Conn L., Stephens D., et al. Cryptococcosis: population-based multistate active surveillance and risk factors in human immunodeficiency virus-infected persons. J Infect Dis. 1999; 179: 449—454.
12. Elinov N.P. Medical mycology is the science of fungi pathogenic to humans; achievements and problems. Problemy medicinskoi mycologii. 2008; 10(2): 8—10. (in Russian)
13. Senior K. Do we need to pay more attention to cryptococci? Lancet Infect Dis. Russ. ed. 2010; 1(5): 286—288.
14. Vasilyeva N.V. Cryptococci and cryptococcosis at the present stage. Problemy medicinskoi mycologii. 2002; 4 (2): 45—46. (in Russian)
15. Charliеr C., Chretien F., Baudrimont M. et al. Capsule structure changes associated with Cryptococcus neoformans crossing of the blood-brain barrier. Am J Pathol. 2005; 166(2): 421—432.
16. Klimko N.N. Mycoses: diagnosis and treatment. Moscow: Prem'er MT; 2007. 336. (in Russian)
17. Moore D., Robson G., Trinci T. The 21st Century Guidebook to Fungi. New York; 2011. 628.
18. Idnurm A., Bahn Y., Nielsen K., et al. Deciphering the model pathogenic fungus Cryptococcus neoformans. Nat Rev Microbiol. 2005; 3(10): 753—764.
19. Volkova O.E., Vengerov Yu.Ya., Safonova A.P., et al. Clinical and pathogenetic features of cryptococcal meningoencephalitis in patients with HIV infection. Jepidemiologija i infekcionnye bolezni. 2014; 19(4): 25—29. (in Russian)
20. Filippova L.V., Frolova E.V. Cryptococcus neoformans and innate immunity. Problemy medicinskoj mikologii. 2011; 13(2): 10—12. (in Russian)
21. Araviysky R.A., Klimko N.N., Vasilyeva N.V. Diagnosis of mycoses. SPb.: Izdatel'skij dom SPbMAPO; 2004. 186. (in Russian)
22. Baddley J., Perfect J., Oster R. Pulmonary criptococcosis in patients without HIV infection: factors associated with disseminated disease. Eur J Clin Microbiol Infect Dis. 2008; 27(10): 937—943.
23. Lesovoy V.S., Lipnitsky A.V. Mycoses of the central nervous system (review). Problemy medicinskoi mycologii. 2008; 10(1): 3—6. (in Russian)
24. Rakhmanova A.G., Lobzin Yu.V., Stepanova E.V., et al. The proportion of mycoses in the structure of secondary diseases in patients with HIV/AIDS. Problemy medicinskoi mycologii. 2004; 6(1): 9—12. (in Russian)
25. Klimko N.N. Diagnostics and treatment of mycoses in intensive care units. Moscow; 2010. 87. (in Russian)
Review
For citations:
Korovkin V., Katibnikova E., Khlopkov S., Martynyuk A., Chistaya D. Cryptococcal-tuberculous meningoencephalitis in a patient with hiv infection: literature review and personal observation. Healthcare. 2025;1(11):57-64. (In Russ.) https://doi.org/10.65249/1027-7218-2025-11-57-64
