Structure and comparative analysis of comorbid conditions in children with anemia of prematurity
Abstract
Objective. To analyze the spectrum and frequency of comorbid conditions in children with early anemia of prematurity depending on the gestational age.
Materials and methods. A retrospective cohort study was conducted of 110 premature newborns with early anemia of prematurity. The babies was divided depending on the gestational age at birth into 3 groups: group 1— up to 28 weeks of gestation (n = 16); group 2 — with a gestational age of 28—31 weeks (n = 63); group 3 — with a gestational age of 32—37 weeks (n = 31). We were analyzed the absolute majority of pathological conditions that preceded or accompanied the development of early anemia of prematurity in children. Statistical calculations were carried out in the R statistical package, version 4.3.
Results. In this cohort were not installed statistically significant difference in the timing of manifestation of early anemia of prematurity depending on the gestational age at birth. There is a statistically significant trend towards a decrease in the number of such serious diseases as retinopathy of prematurity and bronchopulmonary dysplasia, with increasing gestational age in premature infants with anemia. We was revealed a decrease in the incidence of congenital pneumonia and neonatal sepsis with increasing gestational age. At the same time, a statistically significant trend is recorded towards an increase in the frequency of an unspecified infection specific to the perinatal period with increasing gestational age.
Conclusion. The identified trends in the analysis of comorbid conditions in premature infants of different gestational ages with anemia are most likely associated with a defect in immune-endocrine regulation due to premature birth. The increased frequency of infection specific to the perinatal period in the group of newborns with late prematurity is due to a higher level of organism reactivity in children with a longer gestation period, which limits the process of generalization and severe course of the infection.
About the Authors
A. Kozarezova
Клинический родильный дом Минской области
Belarus
Belarus
N. Klimkovich
Белорусский государственный медицинский университет
Belarus
Belarus
O. Krasko
Объединенный институт проблем информатики НАН Беларуси
Belarus
Belarus
А. Sukharava
Клинический родильный дом Минской области
Belarus
Belarus
S. Beresten
Республиканский научно-практический центр «Мать и дитя»
Belarus
Belarus
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Review
For citations:
Kozarezova A., Klimkovich N., Krasko O., Sukharava А., Beresten S. Structure and comparative analysis of comorbid conditions in children with anemia of prematurity. Healthcare. 2025;(5):19-26. (In Russ.)
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