Iron deficiency and anemia in children with juvenile idiopathic arthritis

Objective. To study and identify patterns of development of anemic syndrome in children with juvenile idiopathic arthritis based on clinical manifestations, ferrokinetic parameters, and inflammation markers.

Materials and methods. The study was performed on the basis of the ME «2nd City Children^'s Clinical Hospital» in Minsk. Determination of serum iron, ferritin, transferrin, erythropoietin, latent serum iron-binding capacity (LJCC), concentration of interleukins-6 and -10, tumor necrosis factor-α(TNF-α) in the blood was carried out on the Multiskan enzyme immunoassay analyzer, based From the data obtained, the total serum iron-binding capacity (TIBC) and the percentage of transferrin saturation (TSAT) were calculated.

Results. Disorders in the form of anemia, latent and prelatent iron deficiency were diagnosed in 67,7±5,8 % of children with articular and systemic forms of JIA. At the same time, anemia was detected in 32,3±5,8 % of patients, in other cases there was latent (23,1±9,6 %) and prelatent (12,3±4,1 %) iron deficiency. Among the studied laboratory signs of inflammatory activity, a significant effect on the development of iron metabolism disorders was reflected by such markers as: ESR (H=21,9; p<0,001), CRP (H=8,7; p=0,03), interleukin-6 (H=18,8; p<0,001). Correlation analysis of red blood parameters and iron metabolism with markers of inflammation revealed a number of features depending on the type of iron metabolism disorder. Conclusion. JIA contributes to the development of anemia in every third child, the remaining third of patients have latent and prelatent iron deficiency. More pronounced changes in the values of laboratory signs of iron deficiency and anemia were noted in the systemic form of the disease.

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