Pulmonary emphysema: from molecular mechanisms to personalized therapy
https://doi.org/10.65249/1027-7218-2026-7-58-66
Abstract
This article presents a modern definition of pulmonary emphysema, diagnostic and modern methods of differentiated and surgical treatment. The role of rehabilitation and preventive measures in preventing the development of a disability in patients with pulmonary emphysema is discussed.
About the Authors
I. LaptevaBelarus
A. Laptev
Belarus
I. Orlova
Belarus
References
1. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (2026 Report). Available at: https://goldcopd.org/wp-content/uploads/2026/01/GOLD-REPORT-2026-v1.3-8Dec2025_WMV2.pdf (accessed: 19.07.2026).
2. Arzamasova L.N., Vasil'ev Y.A., Vladzimirskijy A.V., Arzamasov K.M. Pulmonary emphysema prevalence according to radiography and computed tomography. Menedzher zdravoohraneniya. 2026; 5: 85–95. (in Russian)
3. Russian Respiratory Society. Alpha-1-antitrypsin deficiency in adults. – Moscow; 2017. Available at: https://spulmo.ru/download/Rekomend_Antitripsin.pdf (accessed: 19.07.2026). (in Russian)
4. Avdeev S.N., Ajsanov Z.R., Leshсhenko I.V., Belevskij A.S. New algorithm for initial and subsequent therapy of chronic obstructive pulmonary disease. Pul'monologiya. 2026; 36(1): 95–106. (in Russian)
5. Gol'dshtejn V.D. Pulmonary emphysema in clinical practice. Moscow: BINOM; 2016. 176. (in Russian)
6. Hermann E.A., Motahari A., Hoffman E.A., et al. Associations of pulmonary microvascular blood volume with per cent emphysema and CT emphysema subtypes in the community. Thorax. 2025; 80(5): 309–317.
7. Liyan Bo, Xu He, Yan Chen, et al. Lung volume reduction therapies in patients with emphysema. COPD. 2025; 22(1). doi: 10.1080/15412555.2025.2567022.
8. Plechev V.V., Avzaletdinov A.M., Ganiev R.F., et al. Clinical case of prolonged endobronchial valve treatment in severe chronic obstructive pulmonary disease. Kreativnaya hirurgiya i onkologiya. 2026; 16(1): 81–89. (in Russian)
9. Berikhanov Z.G., Nikolaev A.M., Seregina V.Yu. Treatment of chronic obstructive pulmonary disease and emphysema. Hirurgiya. Zhurnal im. N.I. Pirogova. 2023; (9): 79–85. (in Russian)
Review
For citations:
Lapteva I., Laptev A., Orlova I. Pulmonary emphysema: from molecular mechanisms to personalized therapy. Healthcare. 2026;1(7):58-66. (In Russ.) https://doi.org/10.65249/1027-7218-2026-7-58-66
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