Analysis of the results of surgical treatment of sinonasal inverted papilloma in a comparative aspect

Objective. То analyze the long-term results of surgical treatment of sinonasal inverted papilloma using the developed method in a comparative aspect.
Materials and methods. The study material was based on the data of 82 patients diagnosed with sinonasal inverted papilloma: the main (prospective) group included 31 patients operated on using the developed method of surgical treatment of sinonasal inverted papilloma, the control (retrospective) group included 51 patients operated on with various methods of surgical treatment in healthcare institutions of the Republic of Belarus from 2010 to 2023, observed at the N. N. Alexandrov National Cancer Centre. The effectiveness of these methods was analyzed based on data on relapse-free survival, length of hospital stay, and the incidence of metachronous malignancy
Results. Analysis of the immediate results of surgical treatment of sinonasal inverted papilloma revealed the absence of complications associated with the incision of the soft tissues of the face, the mucous membrane of the vestibule of the mouth, and the intersection of the branches of the infraorbital nerve (anterior and middle superior alveolar nerves) in connection with surgical treatment using an endoscopic endonasal approach.
During observation, relapses of sinonasal inverted papilloma developed in 33 (64,7 %) patients in the retrospective group, and in 5 (16,1 %) patients in the prospective group. 1-year disease-free survival in the study group was 90,3 (SE 5,3), 2-year— 82,3 (SE 7,4), in the control group — 60,8 (SE 6,8), and 54,9 (SE 7,0) respectively The average length of stay in the hospital for patients in the prospective group was 4,5 (95 %CI (3,9—5,2) bed days, versus 6,3 (95 % Cl (5,2—7,5) in the retrospective group, the differences are statistically significant (p=0,027).
In the prospective study group, no cases of metachronous malignancy were recorded; in the retrospective group, metachronous carcinoma was diagnosed in 2 (3,9 %) patients.
Conclusion. A method of surgical treatment of sinonasal inverted papilloma has been developed and implemented, which allows minimizing the trauma of surgical intervention, increasing relapse-free survival compared to previously used methods, reducing the length of patient stay in the hospital; no cases of metachronous malignancy were recorded during the observation period.

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