Web-application of model study of the effectiveness of radiation doses when the treatment schedule is modified

The aim of our study is to optimize calculations related to the evaluation of radiation doses when the radiation treatment schedule changes, by simulating such changes in the Web-application «Linear-quadratic model for medical physicists and radiation oncologists», developed on the basis of the theory of linear-quadratic model. As a model study material, we considered the case of changing the radiation treatment regimen in the mode of dose per fraction 2,66Gy to 42,56 Gy, α/β 3 Gy with an interruption that increases the number of days of treatment from 22 to З1. The evaluation was made of the decrease in the effectiveness of the delivered radiation doses when a break occurs in radiation treatment, if the missed fractions are transferred to the end of the RT course without adjusting the dose per fraction; the possibility of compensating for the loss in the effectiveness of the supplied radiation doses was determined by transferring the missed days to Saturday and carrying out fractions twice a day on some days of treatment, as well as taking into account proliferation; It is considered how much the dose needs to be changed per fraction to achieve the effect planned at the start of treatment.

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