Влияние COVID-19 на акушерские и перинатальные исходы у женщин, инфицированных SARS-Cov-2
Аннотация
Пандемия COVID-19, вызванная вирусом SARS-CoV-2, привела к высокой заболеваемости и смертности во всем мире. Появление вакцин стало прорывом в борьбе с SARS-CoV-2, однако возможность возникновения новой волны пандемии из-за мутаций вируса сохраняется. Особую обеспокоенность вызывает влияние SARS-CoV-2 на исходы для матери и плода.
Цель исследования. Анализ опубликованных данных о влиянии COVID-19 на акушерские и перинатальные исходы.
Материал и методы. Проведен анализ открытых полнотекстовых публикаций за 2020—2023 гг. Были включены исследования, изучавшие связь COVID-19 во время беременности с акушерскими и перинатальными исходами.
Результаты. Приведены сведения о патогенезе акушерских и перинатальных осложнений у беременных с COVID-19. Проанализированы представленные на текущий момент сведения о течении беременности у пациенток с COVID-19. Отмечено, что беременные подвергаются повышенному риску тяжелого течения COVID-19, а материнская инфекция SARS-CoV-2 увеличивает риск неблагоприятных исходов для матери и плода.
Заключение. Необходимо изучение влияния SARS-CoV-2 на течение и исходы беременности и родов в зависимости от сроков инфицирования иклинического течения COVID-19.
Об авторе
Т. В. Зновец
З-я городская клиническая больница им. Е. В. Клумова
Беларусь
Беларусь
Зновец Татьяна Владимировна — зам. главного врача по родовспоможению.
Ул. Ленина, 30, 220030, г. Минск.
Сл. тел. +37S 17 327-86-28.
Список литературы
1. World Health Organization COVID-19. Available at: https://covid19.who.int (accessed 24 September 2023).
2. Statement on the fifteenth meeting of the IHR (200S) Emergency Committee on the COVID-19 pandemic. Available at: https://www.who.int/ru/news/item/0S-0S-2023statement-on-the-fifteenth-meeting-of-the-internationalhealth-regulations-(200S)-emergency-committee-regardingthe-coronavirus-disease-(covid-19)-pandemic (accessed 17 September 2023).
3. FavilliA., Mattei Gentili M, De Paola F. et al. COVID-19 and pregnancy: an updated review about evidence-based therapeutic strategies. J. Pers. Med. 2023; 13 (7): 103S.
4. Narang K., Enninga E. A. L., Gunaratne M. D. S. K. et al. SARS-CoV-2 infection and COVID-19 during pregnancy: a multidisciplinary review. Mayo Clin. Proc. 2020; 9S (8): 17S0—6S.
5. Cavalcante M. B., Cavalcante C. T, Sarno M. et al. Maternal immune response and obstetrical outcomes of pregnant women with COVID-19 and possible health risks of offspring. Am. J. Reprod. Immunol. 2021; 143: 1032S0.
6. Alifano M., Alifano P., Forgez P., Iannelli A. Reninangiotensin system at the heart of COVID-19 pandemic. Biochimie. 2020; 174: 30—3.
7. Hoffmann M., Kleine-Weber H., Schroeder S. et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181: 271—80.
8. Obuchowska A., Standylo A., Obuchowska K. et al. Cytokine storms in the course of COVID-19 and haemophagocytic lymphohistiocytosis in pregnant and postpartum women. Biomolecules. 2021; 11 (8): 1202.
9. Gubernatorova E. O., Gorshkova E. A., Polinova A. I., Drutskaya M. S. IL-6: Relevance for immunopathology of SARS-CoV-2. Cytokine Growth Factor Rev. 2020; S3: 13—24.
10. Royal College of Obstetricians and Gynecologists. Coronavirus (COVID-19), infection in pregnancy. 2022. Available at: https://www.rcog.org.uk/guidance/coronaviruscovid-19-pregnancy-and-women-s-health/coronaviruscovid-19-infection-in-pregnancy (accessed 17 September 2023).
11. Bellos I., Pandita A., Panza R. Maternal and perinatal outcomes in pregnant women infected by SARS-CoV-2: A meta-analysis. Eur. J. Obstet. Gynecol. Reprod. Biol. 2021; 2S6: 194—204.
12. Zambrano L. D., Ellington S., Strid P et al. Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status — United States, January 22 — October 3, 2020. MMWR Morb. Mortal. Wkly Rep. 2020; 69: 1641—7.
13. Ellington S., Strid P., Tong V. T et al. Characteristics of women of reproductive age with laboratory-confirmed SARSCoV-2 infection by pregnancy status — United States, January 22 — June 7, 2020. MMWR Morb. Mortal. Wkly Rep. 2020; 69 (2S): 769—7S.
14. Januszewski M., Ziuzia-Januszewska L., Jakimiuk A. A. et al. Is the course of COVID-19 different during pregnancy? A retrospective comparative study. Int. J. Environ. Res. Public. Health. 2021; 18 (22): 12011.
15. Collin J., Bystrom E., Carnahan A., Ahrne M. Public Health Agency of Sweden’s Brief Report: Pregnant and postpartum women with severe acute respiratory syndrome coronavirus 2 infection in intensive care in Sweden. Acta Obstet. Gynecol. Scand. 2020; 99 (7): 819—22.
16. Update to living systematic review on COVID-19 in pregnancy. BMJ. 2021; 372: n61S.
17. Stock S. J., Carruthers J., Calvert C. et al. Author correction: SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland. Nat. Med. 2022; 28: S99.
18. Badr D. A., Mattern J., Carlin A. et al. Are clinical outcomes worse for pregnant women at e”20 weeks’ gestation infected with coronavirus disease 2019? A multicenter casecontrol study with propensity score matching. Am. J. Obstet. Gynecol. 2020; 223: 764—8.
19. Allotey J., Stallings E., Bonet M. et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020; 370: m3320.
20. Vouga M., Favre G., Martinez-Perez O. et al. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Sci. Rep. 2021; 11 (1): 13898.
21. Galang R. R., Newton S. M., Woodworth K. R. et al. Risk factors for illness severity among pregnant women with confirmed severe acute respiratory syndrome coronavirus 2 infection-surveillance for emerging threats to mothers and babies network, 22 state, local, and territorial health departments, 29 March2020— SMarch 2021. Clin. Infect. Dis. 2021; 73: S17—S23.
22. Smith E. R, Oakley E., Grandner G. W. et al. Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: a sequential, prospective meta-analysis. Am. J. Obstet. Gynecol. 2023; 228 (2): 161—77.
23. Knight M., Bunch K., Vousden N. et al. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study. BMJ. 2020; 369: m2107.
24. Misra S. S., Ahirwar A.K., Sakarde A. et al. COVID-19 infection in pregnancy: a review of existing knowledge. Horm. Mol. Biol. Clin. Investig. 2022; 43 (3): 373—8.
25. Dashraath P., Wong J. L. J., Lim M. X. K. et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am. J. Obstet. Gynecol. 2020; 222 (6): S21—31.
26. Nana M., Hodson K., Lucas N. et al. Diagnosis and management of COVID-19 in pregnancy. BMJ. 2022; 377: e069739.
27. Afshar Y, Gaw S. L., Flaherman V. J. et al. Clinical presentation of coronavirus disease 2019 (COVID-19) in pregnant and recently pregnant people. Obstet. Gynecol. 2020; 136: 1117—2S.
28. Saccone G., Carbone F. I., Zullo F. The novel coronavirus (2019-nCoV) in pregnancy: what we need to know. Eur. J. Obstet. Gynecol. Reprod. Biol. 2020; 249: 92—3.
29. Kariyanna P. T., Aurora L., Jayarangaiah A. et al. Utility of d-dimer as a prognostic factor in SARS CoV2 infection: A Review. Am. J. Med. Case Rep. 2020; 8 (10): 337—40.
30. Chi J., Gong W., Gao Q. Clinical characteristics and outcomes of pregnant women with COVID-19 and the risk of vertical transmission: a systematic review. Arch. Gynecol. Obstet. 2021; 303 (2): 337—4S.
31. Mendoza M., Garcia-Ruiz I., Maiz N. et al. Preeclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG. 2020; 127 (11): 1374—80.
32. Villar J., Ariff S., Gunier R. B. et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID multinational cohort study. JAMA Pediatr. 2021; 17S: 817—26.
33. La Verde M., Riemma G., Torella M. et al. Maternal death related to COVID-19: A systematic review and metaanalysis focused on maternal co-morbidities and clinical characteristics. Int. J. Gynaecol. Obstet. 2021; 1S4 (2): 212—19.
34. Simbar M., Nazarpour S., Sheidaei A. Evaluation of pregnancy outcomes in mothers with COVID-19 infection: a systematic review and meta-analysis. J. Obstet. Gynaecol. 2023; 43 (1): 2162867.
35. Барановская E. И. Материнская смертность в современном мире. Акушерство, гинекология и репродукция. 2022; 16 (3): 296—30S.
36. Lokken E. M., Huebner E. M., Taylor G. G. et al. Disease severity, pregnancy outcomes, and maternal deaths among pregnant patients with severe acute respiratory syndrome coronavirus 2 infection in Washington State. Am. J. Obstet. Gynecol. 2021; 22S: 77.e1—77.e14.
37. Wastnedge E. A. N., Reynolds R. M., van Boeckel S. R. et al. Pregnancy and COVID-19. Physiol. Rev. 2021; 101 (1): 303—18.
38. Lippi G., Henry B. M., Sanchis-Gomar F., Mattiuzzi C. Updates on laboratory investigations in coronavirus disease 2019 (COVID-19). Acta Biomed. 2020; 91 (3): e2020030.
39. Giardini V., Ornaghi S., Gambacorti-Passerini C. et al. Imbalanced angiogenesis in pregnancies complicated by SARS-CoV-2 infection. Viruses. 2022; 14 (10): 2207.
40. Stepan H., Hund M., Andraczek T. Combining biomarkers to predict pregnancy complications and redefine preeclampsia: the angiogenic-placental syndrome. Hypertension. 2020; 7S (4): 918—26.
41. Wei S. Q., Bilodeau-Bertrand M., Liu S., Auger N. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. CMAJ. 2021; 193 (16): ES40— ES48.
42. Metz T. D., Clifton R. G., Hughes B. L. et al. Disease severity and perinatal outcomes of pregnant patients with coronavirus disease 2019 (COVID-19). Obstet. Gynecol. 2021; 137: S71—80.
43. Liu D., Li L., Wu X. et al. Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: a preliminary analysis. AJR Am. J. Roentgenol. 2020; 21S (1): 127—32.
44. Yu N., Li W., Kang Q. et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect. Dis. 2020; 20: SS9—64.
45. DeSisto C. L., Wallace B., Simeone R. M. et al. Risk for stillbirth among women with and without COVID-19 at delivery hospitalization — United States, March 2020September 2021. MMWR Morb. Mortal. Wkly Rep. 2021; 70 (47): 1640—4S.
46. Capobianco G., Saderi L., Aliberti S. et al. COVID-19 in pregnant women: a systematic review and meta-analysis. Eur. J. Obstet. Gynecol. Reprod. Biol. 2020; 2S2: S43—S8.
47. Jafari M., Pormohammad A., Sheikh Neshin S. A. et al. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis. Rev. Med. Virol. 2021; 31 (S): 1—16.
48. Mazur-Bialy A. I., Kolomanska-Bogucka D., Tim S., Oplawski M. Pregnancy and childbirth in the COVID-19 era — the course of disease and maternal-fetal transmission. J. Clin. Med. 2020; 9 (11): 3749.
49. Zhang L., Jiang, Y., Wei M. et al. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. Zhonghua Fu Chan Ke Za Zhi. 2020; SS (3): 166—71.
50. Schwartz D. A. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of
51. Diriba K., Awulachew E., Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARSCoV) during pregnancy and the possibility of vertical maternal-fetal transmission: a systematic review and metaanalysis. Eur. J. Med. Res. 2020; 2S (1): 39.
52. Gurol-Urganci I., Jardine J. E., Carroll F et al. Maternal and perinatal outcomes of pregnant women with SARS-CoV2 infection at the time of birth in England: National cohort study. Am. J. Obstet. Gynecol. 2021; 22S(S): S22.e1—S22.e11.
53. Белокриницкая T E., Артымук H. В., Филиппов О. С., Фролова H. И. Клиническое течение, материнские и перинатальные исходы новой коронавирусной инфекции COVID-19 у беременных Сибири и Дальнего Востока. Акушерство и гинекология. 2021; 2: 48—S4.
54. Zaigham M., Andersson O. Maternal and perinatal outcomes with COVID-19: a systematic review of 108 pregnancies. Acta Obstet. Gynecol. Scand. 2020; 99 (7): 823—29.
55. Yang R., Mei H., Zheng T et al. Pregnant women with COVID-19 and risk of adverse birth outcomes and maternalfetal vertical transmission: a population-based cohort study in Wuhan, China. BMC Med. 2020; 18 (1): 330.
56. Shuffrey L. C., Firestein M. R., Kyle M. H. et al. Association of birth during the COVID-19 pandemic with neurodevelopmental status at 6 months in infants with and without in utero exposure to maternal SARS-CoV-2 infection. JAMA Pediatr. 2022; 176 (6): e21SS63.
57. Edlow A. G., Castro V. M., Shook L. L. et al. Neurodevelopmental outcomes at 1 year in infants of mothers who tested positive for SARS-CoV-2 during pregnancy. JAMA Netw. Open. 2022; S (6): e221S787.
58. Deoni S. Impact of the COVID-19 pandemic environment on early child brain and cognitive development. Biol. Psychiatry. 2022; 91 (9): S26.
59. Chmielewska B., Barratt I., Townsend R. et al. Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis. Lancet Glob. Health. 2021; 9(6): e7S9—e772.
60. Alzamora M. C., Paredes T., Caceres D. et al. Severe COVID-19 during pregnancy and possible vertical transmission. Am. J. Perinatol. 2020; 37 (8): 861—S.
61. Zaigham M., Holmberg A., Karlberg M. L. et al. Intrauterine vertical SARS-CoV-2 infection: a case confirming transplacental transmission followed by divergence of the viral genome. BJOG. 2021; 128 (8): 1388—94.
62. Vivanti A. J., Vauloup-Fellous C., Prevot S. et al. Transplacental transmission of SARS-CoV-2 infection. Nat. Commun. 2020; 11: 3S72.
63. Mofenson L. M., Idele P., Anthony D. et al. The evolving epidemiologic and clinical picture of SARS-CoV-2 and COVID-19 disease in children and young people. 2020. Available at: https://www.unicef-irc.org/publications/pdf/Evolving-Epidemiologic-Clinical-Picture-SARS-CoV2COVID-19-Children-Young-People.pdf.
64. Edlow A. G., Li J. Z., Collier A. Y. et al. Assessment of maternal and neonatal SARS-CoV-2 viral load, transplacental antibody transfer, and placental pathology in pregnancies during the COVID-19 pandemic. JAMA Netw Open. 2020; 3(12): e20304SS.
65. Ouyang Y., Bagalkot T., Fitzgerald W. et al. Term human placental trophoblasts express SARS-CoV-2 entry factors ACE2, TMPRSS2, and Furin. mSphere. 2021; 6 (2): e002S0-21.
66. Chambers C., Krogstad P., Bertrand K. et al. Evaluation for SARS-CoV-2 in breast milk from 18 infected women. JAMA. 2020; 324: 1347—8.
67. Gross R., Conzelmann C., Muller J. A. et al. Detection of SARS-CoV-2 in human breastmilk. Lancet. 2020; 39S: 17S7—8.
68. Salvatore C. M., Han J. Y., Acker K. P. et al. Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study. Lancet Child. Adolesc. Health. 2020; 4: 721—7.
69. Raschetti R., Vivanti A. J., Vauloup-Fellous C. et al. Synthesis and systematic review of reported neonatal SARSCoV-2 infections. Nat. Commun. 2020; 11: S164.
70. Centers for Disease Control and Prevention. Evaluation and management considerations for neonates at risk for COVID-19. 2020. Available at: https://www.cdc.gov/coronavirus/2019-ncov/hcp/caring-fornewborns.html#mother-neonatal-contact (accessed 22 September 2023).
Рецензия
Для цитирования:
Зновец Т.В. Влияние COVID-19 на акушерские и перинатальные исходы у женщин, инфицированных SARS-Cov-2. Здравоохранение. 2024;(3):10-21.
For citation:
Znovets T.V. Impact of COVID-19 on obstetric and perinatal outcomes in women infected with SARS-CoV-2. Healthcare. 2024;(3):10-21. (In Russ.)
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