Genetic predictors of disturbances in central hemodynamic parameters in the perioperative period during cardiac surgery
Abstract
Objective. Analysis of polymorphisms of angiotensin type 1 receptor (AGT2R1), endothelin-1 gene (Lys198Asn), endothelial nitric oxide synthase gene NOS3 (С786Т) as potential predictors of the development of unstable hemodynamics in the intraoperative period during cardiac surgery for myocardial revascularization.
Materials and methods. An analysis was carried out of more than thirty domestic and foreign sources on the influence of polymorphisms of AGT2R1, Lys198Asn, С786Т on various diseases of systems and organs of the human body.
Results. Polymorphisms of the AGT2R1, Lys198Asn, and С786Т affect the development and progression of major diseases of the cardiovascular system.
Conclusion. It can be assumed that the above polymorphisms can be considered predictors of disturbances in central hemodynamic parameters in the perioperative period during cardiac surgery.
About the Authors
K. O. Kratkou
Гродненский областной клинический кардиологический центр
Belarus
Belarus
R. E. Yakubtsevich
Гродненский государственный медицинский университет
Belarus
Belarus
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Review
For citations:
Kratkou K.O., Yakubtsevich R.E. Genetic predictors of disturbances in central hemodynamic parameters in the perioperative period during cardiac surgery. Healthcare. 2024;(3):28-35. (In Russ.)
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