Hematological parameters and the nature of the inflammatory response in the body of rats after implantation of vascular grafts

Objective. To investigate changes in hematologic parameters and inflammatory response after implantation of biological and synthetic vascular grafts.

Materials and methods. The study was performed on male Wistar laboratory rats (n = 75). The animals were divided into three groups: group 1 — false-operated (25 animals); group 2 — implantation of fragment of biological vascular graft (25 animals); group 3 — implantation of fragment of synthetic vascular graft (25 animals). Blood was collected from the animals on days 3, 7, 14, 21 and 30 after surgery. The numbers of white blood cells, neutrophils, lymphocytes, monocytes and eosinophils, red blood cells, platelet count, hemoglobin concentration and C-reactive protein were measured in the blood.

Results. On the 3^rd day after operation, statistically significant differences were found in white blood cell counts between groups 1 and 2 (p = 0,042) and between groups 2 and 3 (p = 0,024). On the 7^th day after operation, there were no statistically or clinically significant differences between the animal groups. On the 14^th day statistically significant differences were found between groups 2 and 3 in hemoglobin concentration (p = 0,023) and red blood cells count (p = 0,043); on the 21^st and 30^th days, no statistically or clinically significant differences were found between the animal groups.

Conclusion. There were no clinically significant changes in red blood cells count, platelet count, hemoglobin concentration, white blood cells count or C-reactive protein concentration compared to animals in the control group.

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